General Information

    • DRAMP ID

    • DRAMP00198

    • Peptide Name

    • Microcin H47 (MccH47; Bacteriocin)

    • Source

    • Escherichia coli (Gram-negative bacteria)

    • Family

    • Belongs to the class IIb microcin

    • Gene

    • mchB

    • Sequence

    • GGAPATSANAAGAAAIVGALAGIPGGPLGVVVGAVSAGLTTGIGSTVGSGSASSSAGGGS

    • Sequence Length

    • 60

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00198 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00198.

Physicochemical Information

    • Formula

    • C204H343N61O75

    • Absent Amino Acids

    • CDEFHKMQRWY

    • Common Amino Acids

    • G

    • Mass

    • 4850.33

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 26

    • Net Charge

    • 0

    • Boman Index

    • 47.56

    • Hydrophobicity

    • 0.837

    • Aliphatic Index

    • 91.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 31

DRAMP00198

DRAMP00198 chydropathy plot

Comments Information

    • Function

    • Bactericidal antibiotic. Active on bacteria phylogenetically related to the producing strain.

Literature Information

  • ·Literature 1

    • Title

    • The structural gene for microcin H47 encodes a peptide precursor with antibiotic activity.

    • Reference

    • Antimicrob Agents Chemother. 1999 Sep;43(9):2176-2182.

    • Author

    • Rodr­guez E, Gaggero C, Lavi±a M.
  • ·Literature 2

    • Title

    • The structure, function, and origin of the microcin H47 ATP-binding cassette exporter indicate its relatedness to that of colicin V.

    • Reference

    • Antimicrob Agents Chemother. 2001 Mar;45(3):969-972.

    • Author

    • Azpiroz MF, Rodr­guez E, Lavi±a M.