General Information

    • DRAMP ID

    • DRAMP00202

    • Peptide Name

    • Thiocillin (Bacteriocin)

    • Source

    • Bacillus cereus); also Bacillus badius

    • Family

    • Belongs to the thiocillin family

    • Gene

    • Not found

    • Sequence

    • SCTTCVCTCSCCTT

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00202 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00202.

Physicochemical Information

    • Formula

    • C49H86N14O22S6

    • Absent Amino Acids

    • ADEFGHIKLMNPQRWY

    • Common Amino Acids

    • C

    • Mass

    • 1415.66

    • PI

    • 5.23

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 1

    • Net Charge

    • 0

    • Boman Index

    • -7.93

    • Hydrophobicity

    • 1.007

    • Aliphatic Index

    • 20.71

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 28.85

    • Polar Residues

    • 13

DRAMP00202

Comments Information

    • Function

    • Has bacteriocidal activity against Gram-positive bacteria, but not against Gram-negative bacteria. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu).

    • PTM

    • Maturation of thiazole and oxazole containing antibiot

Literature Information

  • ·Literature 1

    • Title

    • Structural studies on thiocillins I, II and III (studies on antibiotics from the genus Bacillus XXIX).

    • Reference

    • J Antibiot (Tokyo). 1976 Apr;29(4):366-374.

    • Author

    • Shoji J, Kato T, Yoshimura Y, Tori K.
  • ·Literature 2

    • Title

    • Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin P. Studies on antibiotics from the genus Bacillus. VIII.

    • Reference

    • J Antibiot (Tokyo). 1981 Sep;34(9):1126-1136.

    • Author

    • Shoji J, Hinoo H, Wakisaka Y, Koizumi K, Mayama M.