General Information

    • DRAMP ID

    • DRAMP00203

    • Peptide Name

    • Thiocillin GE2270 (Antibiotic GE2270; Bacteriocin)

    • Source

    • Planobispora rosea (Gram-positive bacteria)

    • Family

    • Belongs to the thiocillin family

    • Gene

    • Not found

    • Sequence

    • SCNCVCGFCCSCSP

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00203 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00203.

Physicochemical Information

    • Formula

    • C52H81N15O19S6

    • Absent Amino Acids

    • ADEHIKLMQRTWY

    • Common Amino Acids

    • C

    • Mass

    • 1412.66

    • PI

    • 5.23

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • -1.2

    • Hydrophobicity

    • 1.007

    • Aliphatic Index

    • 20.71

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 28.85

    • Polar Residues

    • 11

DRAMP00203

Comments Information

    • Function

    • inhibits bacterial protein biosynthesis by preventing the formation of a stable complex between the elongation factor Tu (EF-Tu), GTP and tRNA, hindering the activation of EF-Tu.

Literature Information

  • ·Literature 1

    • Title

    • Antibiotic GE2270 A: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.

    • Reference

    • J Antibiot (Tokyo). 1991 Jul;44(7):693-701.

    • Author

    • Selva E, Beretta G, Montanini N, Saddler G.S, Gastaldo L, Ferrari P, Lorenzetti R, Landini P, Ripamonti F, Goldstein B.P, Berti M, Montanaro L, Denaro M.