• DRAMP ID

    • DRAMP00204
    • Peptide Name

    • Thiocillin GE37468 (Antibiotic GE37468; Bacteriocin)
    • Source

    • Streptomyces sp. (Gram-positive bacteria)
    • Family

    • Belongs to the thiocillin family
    • Gene

    • getA
    • Sequence

    • STNCFCYPCCSCSS
    • Sequence Length

    • 14
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Bacillus subtilis (MIC=0.047 µg/ml), Staphylococcus aureus (MRSA) (MIC=0.047 µg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP00204 helical wheel diagram
    • Formula

    • C58H85N15O22S5
    • Absent Amino Acids

    • ADEGHIKLMQRVW
    • Common Amino Acids

    • C
    • Mass

    • 1736.75
    • PI

    • 5.66
    • Basic Residues

    • 0
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 1
    • Boman Index

    • -13.57
    • Hydrophobicity

    • 35.71
    • Aliphatic Index

    • 0
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1740
    • Absorbance 280nm

    • 133.85
    • Polar Residues

    • 12

DRAMP00204

    • Function

    • Has bacteriocidal activity against both aerobic and anaerobic Gram-positive bacteria. Has poor activity against Gram-negative bacteria, with the exception of B.fragilis. Inhibits bacterial protein biosynthesis by acting on elongation factor Tu (
  • Literature 1
    • Reference

    • Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13053-13058.
    • Author

    • Young TS, Walsh CT.
    • Title

    • Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.