General Information
-
DRAMP ID
- DRAMP00205
-
Peptide Name
- Tricyclic peptide RP 71955 (Bacteriocin)
-
Source
- Streptomyces sp. (strain SP9440) (Gram-positive bacteria)
-
Family
- Belongs to the class 1 lasso peptide
-
Gene
- Not found
-
Sequence
- CLGIGSCNDFAGCGYAVVCFW
-
Sequence Length
- 21
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- Virus: HIV-1
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Cyclization of a N-terminal between Cys1 and Asp9
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys1 and Cys 13,Cys 7 and Cys19.
-
Stereochemistry
- L
-
Structure
- Beta strand
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
Predicted Structure
- There is no predicted structure for DRAMP00205.
Physicochemical Information
-
Formula
- C97H137N23O27S4
Absent Amino Acids
- EHKMPQRT
Common Amino Acids
- CG
Mass
- 2185.53
PI
- 3.8
Basic Residues
- 0
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- -1
-
Boman Index
- 19.81
Hydrophobicity
- 1.157
Aliphatic Index
- 74.29
Half Life
-
- Mammalian:1.2 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7240
Absorbance 280nm
- 362
Polar Residues
- 11
DRAMP00205
Comments Information
Function
- Active against HIV-1 virus in vitro.
Literature Information
- ·Literature 1
-
Title
- Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.
-
Pubmed ID
- 8270499
-
Reference
- J Antibiot (Tokyo). 1993 Nov;46(11):1756-1757.
-
Author
- Helynck G, Dubertret C, Mayaux JF, Leboul J.
- ·Literature 2
-
Title
- Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus.
-
Pubmed ID
- 8286361
-
Reference
- Biochemistry. 1994 Jan 11;33(1):42-50.
-
Author
- Fréchet D, Guitton JD, Herman F, Faucher D, Helynck G, Monegier du Sorbier B, Ridoux JP, James-Surcouf E, Vuilhorgne M.