• DRAMP ID

    • DRAMP00218
    • Peptide Name

    • Plantazolicin (PZN; Bacteriocin)
    • Source

    • Bacillus amyloliquefaciens FZB42 & Bacillus pumilus (Bacillus mesentericus) (Gram-positive bacteria)
    • Family

    • Unknown
    • Gene

    • pznA
    • Sequence

    • RCTCTTIISSSSTF
    • Sequence Length

    • 14
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Bacillus subtilis HB0042, Bacillus subtilis strain 168, Bacillus megaterium 7A1, Bacillus anthracis (MIC=2-4 µg/ml), Bacillus brevis strain ATCC 8246, Bacillus cereus strain ATCC 14579 and strain CU1065, Bacillus licheniformis strain ATCC 9789, Micrococcus luteus, Bacillus sphaericus, Paenibacillus granivorans and Streptococcus pyogenes (MIC=128 µg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP00218 helical wheel diagram
    • Formula

    • C61H103N17O23S2
    • Absent Amino Acids

    • ADEGHKLMNPQVWY
    • Common Amino Acids

    • ST
    • Mass

    • 1738.75
    • PI

    • 8.23
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 3
    • Boman Index

    • -23.42
    • Hydrophobicity

    • 45
    • Aliphatic Index

    • 55.71
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 9.62
    • Polar Residues

    • 10

DRAMP00218

    • Function

    • Peptide antibiotic inhibiting growth of Gram-positive bacteria
  • Literature 1
    • Reference

    • J Bacteriol. 2011 Jan;193(1):215-224.
    • Author

    • Scholz R, Molohon KJ, Nachtigall J, Vater J, Markley AL, S¼ssmuth RD, Mitchell DA, Borriss R.
    • Title

    • Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42.