General Information

    • DRAMP ID

    • DRAMP00228

    • Peptide Name

    • Bioactive peptide 1 (BAP1; Curvalicin-28a; Bacteriocin)

    • Source

    • Lactobacillus curvatus (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • TPVVNPPFLQQT

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Listeria monocytogenes, Lactococcus lactis subsp lactis and Lactobacillus curvatus H28.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00228 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C62H97N15O18

    • Absent Amino Acids

    • ACDEGHIKMRSWY

    • Common Amino Acids

    • P

    • Mass

    • 1340.54

    • PI

    • 5.19

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • 0

    • Boman Index

    • -6.88

    • Hydrophobicity

    • -0.142

    • Aliphatic Index

    • 80.83

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP00228

Comments Information

    • Function

    • Has antibacterial activity. Has no antifungal activity against S. cerevisiae, Penicillium sp BKS-TAN2 or A. niger.

Literature Information

  • ·Literature 1

    • Title

    • Production of three anti-listerial peptides by Lactobacillus curvatus in MRS broth.

    • Reference

    • Food Res. Intern. 2010;43:33-39.

    • Author

    • Ghalfi H, Benkerroum N, Ongena M, Bensaid M, Thonart P.