General Information

    • DRAMP ID

    • DRAMP00230

    • Peptide Name

    • Lariatins A (lasso peptide; Bacteriocin)

    • Source

    • Rhodococcus jostii K01-B0171 (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GSQLVYREWVGHSNVIKP

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Mycobacterium smegmatis and Mycobacterium tuberculosis.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00230 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00230.

Physicochemical Information

    • Formula

    • C94H145N27O26

    • Absent Amino Acids

    • ACDFMT

    • Common Amino Acids

    • V

    • Mass

    • 2069.35

    • PI

    • 8.6

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -24.89

    • Hydrophobicity

    • -0.411

    • Aliphatic Index

    • 91.67

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 411.18

    • Polar Residues

    • 6

DRAMP00230

DRAMP00230 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure.

    • Reference

    • J Am Chem Soc. 2006 Jun 14;128(23):7486-7891.

    • Author

    • Iwatsuki M, Tomoda H, Uchida R, Gouda H, Hirono S, Omura S.