• DRAMP ID

    • DRAMP00232
    • Peptide Name

    • Cypemycin (Bacteriocin)
    • Source

    • Streptomyces sp. OH-4156 (Gram-positive bacteria)
    • Family

    • Belongs to the linaridin family
    • Gene

    • cypA
    • Sequence

    • ATPATPTVAQFVIQGSTICLVC
    • Sequence Length

    • 22
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

      • Micrococcus luteus (MIC=0.2 µg/ml)
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP00232 helical wheel diagram
    • Formula

    • C98H162N24O30S2
    • Absent Amino Acids

    • DEHKMNRWY
    • Common Amino Acids

    • T
    • Mass

    • 2595.4
    • PI

    • 5.84
    • Basic Residues

    • 0
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Boman Index

    • 14.03
    • Hydrophobicity

    • 110.91
    • Aliphatic Index

    • 106.36
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.95
    • Polar Residues

    • 8

DRAMP00232

DRAMP00232 chydropathy plot
    • Function

    • Antibiotic peptide structurally related to lantibiotics. Has cytotoxic activity against mouse P388 leukemia cells (IC(50)=1.3 μg/ml).
  • Literature 1
    • Reference

    • J Antibiot (Tokyo). 1993 Nov;46(11):1666-1671.
    • Author

    • Komiyama K, Otoguro K, Segawa T, Shiomi K, Yang H, Takahashi Y, Hayashi M, Otani T, Omura S.
    • Title

    • A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics.