General Information
-
DRAMP ID
- DRAMP00236
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Peptide Name
- Halocin-S8 (HalS8; Bacteriocin)
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Source
- Haloarchaeon S8a
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Family
- Not found
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Gene
- halS8
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Sequence
- SDCNINSNTAADVILCFNQVGSCALCSPTLVGGPVP
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Sequence Length
- 36
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UniProt Entry
- Q9HHA8
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Halobacterium salinarum NRC817, Halobacterium GRB and Haloferax gibbonsii.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00236.
Physicochemical Information
-
Formula
- C150H243N41O52S4
Absent Amino Acids
- EHKMRWY
Common Amino Acids
- CNSV
Mass
- 3581.06
PI
- 3.56
Basic Residues
- 0
Acidic Residues
- 2
Hydrophobic Residues
- 13
Net Charge
- -2
-
Boman Index
- -11.17
Hydrophobicity
- 0.564
Aliphatic Index
- 94.72
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 250
Absorbance 280nm
- 7.14
Polar Residues
- 17
DRAMP00236
Comments Information
Function
- Has antibacterial activity.
Miscellaneous
- Halocin-S8 is quite robust, as it can be desalted, boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.
Literature Information
- ·Literature 1
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Title
- Halocin S8: a 36-amino-acid microhalocin from the haloarchaeal strain S8a.
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Pubmed ID
- 10940040
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Reference
- J Bacteriol. 2000 Sep;182(17):4951-4958.
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Author
- Price LB, Shand RF.