General Information

    • DRAMP ID

    • DRAMP00237

    • Peptide Name

    • Halocin-C8 (HalC8; Bacteriocin)

    • Source

    • Halobacterium sp. (strain AS7092)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DIDITGCSACKYAAG

    • Sequence Length

    • 15

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • A wide variety of haloarchaeons.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell wall

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00237 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00237.

Physicochemical Information

    • Formula

    • C61H98N16O23S2

    • Absent Amino Acids

    • EFHLMNPQRVW

    • Common Amino Acids

    • A

    • Mass

    • 1487.66

    • PI

    • 4.21

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -1

    • Boman Index

    • -9.39

    • Hydrophobicity

    • 0.327

    • Aliphatic Index

    • 72

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 115.36

    • Polar Residues

    • 7

DRAMP00237

Comments Information

    • MOA

    • Causes cell lysis and death, possibly by disrupting the cell wall. boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.

Literature Information

  • ·Literature 1

    • Title

    • Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.

    • Reference

    • Extremophiles. 2003 Oct;7(5):401-407.

    • Author

    • Li Y, Xiang H, Liu J, Zhou M, Tan H.