General Information

    • DRAMP ID

    • DRAMP00243

    • Peptide Name

    • Subpeptin JM4-A (Bacteriocin)

    • Source

    • Bacillus subtilis JM4 (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • XXKEIXWIFHDN

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Salmonella, Bacillus cereus, Bacillus megaterium, Lactobacillus casei, Leptostylus viridescens, Lactobacillus plantarum CGMCC 1.3, Myotis flavus, Corynebacterium glutamicum, Corynebacterium crenatum, Leuconostoc mesenteroides, Bacillus thuringiensis, Streptococcus faecalis CGMCC.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00243 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00243.

Physicochemical Information

    • Formula

    • C57H74N14O12

    • Absent Amino Acids

    • ACGLMPQRSTVY

    • Common Amino Acids

    • X

    • Mass

    • 1535.34

    • PI

    • 5.32

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 4

    • Net Charge

    • 0

    • Boman Index

    • -17.23

    • Hydrophobicity

    • -0.558

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:?
      • Yeast:?
      • E.coli:?

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 500

    • Polar Residues

    • 1

DRAMP00243

Comments Information

    • Function

    • Has antibacterial activity against Gram-positive and Gram-negative bacteria.

    • Developmental stage

    • Expressed from the mid-exponential phase, maximum activity is reached at the stationary phase.

    • Biophysicochemical properties

    • pH dependence (Active from pH 2.0 to 8.0. Retains some activity up to pH 12.0); Temperature dependence (Active from 20 to 100 degrees Celsius).

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of two novel antimicrobial peptides Subpeptin JM4-A and Subpeptin JM4-B produced by Bacillus subtilis JM4.

    • Reference

    • Curr Microbiol. 2005 Nov;51(5):292-296.

    • Author

    • Wu S, Jia S, Sun D, Chen M, Chen X, Zhong J, Huan L.