General Information

    • DRAMP ID

    • DRAMP00244

    • Peptide Name

    • Hominicin (Bacteriocin)

    • Source

    • Staphylococcus hominis MBBL 2-9 (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • XTPATPFTPAITEITAAVIAX

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.06 µg/ml), S. aureus ATCC (MRSA) 11435 (MIC=0.96 µg/ml), S. aureus (vancomycin-intermediate VISA) CCARM 3501 (MIC=3.82 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Dimethylation on Ile1

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • ①The residue X at position 1 is DmIle (N1, N1-dimethyl-isoleucine).②The residues T at position 2, 5, 8 and 15 are dehydrobutyrine. ③The residue at position 21 is a distinct residue Dmp (N2, N2-dimethyl-1,2-propanediamine) rarely found from biosynthetic antimicrobial peptides.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00244 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00244.

Physicochemical Information

    • Formula

    • C87H137N19O25

    • Absent Amino Acids

    • CDGHKLMNQRSWY

    • Common Amino Acids

    • AT

    • Mass

    • 2107.85

    • PI

    • 4

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • -1

    • Boman Index

    • 11.17

    • Hydrophobicity

    • 0.843

    • Aliphatic Index

    • 93.33

    • Half Life

      • Mammalian:?
      • Yeast:?
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP00244

DRAMP00244 chydropathy plot

Comments Information

    • Function

    • Hominicin exhibited heat stability up to 121 degrees C for 15min and activity under both acidic and basic conditions (from pH 2.0 to 10.0).

Literature Information

  • ·Literature 1

    • Title

    • Characterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2-9.

    • Reference

    • Biochem Biophys Res Commun. 2010 Aug 20;399(2):133-138.

    • Author

    • Kim PI, Sohng JK, Sung C, Joo HS, Kim EM, Yamaguchi T, Park D, Kim BG.