General Information

    • DRAMP ID

    • DRAMP00247

    • Peptide Name

    • Gramicidin C (GC; Bacteriocin)

    • Source

    • Bacillus brevis (soil bacterium) (Gram-positive bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VGALAVVVWLYLWLW

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antbacterial, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta strand (1 strands; 13 residues)

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00247 helical wheel diagram

    • PDB ID

    • 1JO4 resolved by NMR.
  • 1JO4-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP00247.

Physicochemical Information

    • Formula

    • C94H134N18O17

    • Absent Amino Acids

    • CDEFHIKMNPQRST

    • Common Amino Acids

    • LV

    • Mass

    • 1788.21

    • PI

    • 5.49

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • 0

    • Boman Index

    • 47.25

    • Hydrophobicity

    • 2.08

    • Aliphatic Index

    • 194.67

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 17990

    • Absorbance 280nm

    • 1285

    • Polar Residues

    • 2

DRAMP00247

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles.

    • Reference

    • Biochemistry 2001; 40: 11676-11686.

    • Author

    • Townsley, L.E, Tucker, W.A, Sham, S, Hinton, J.F.