General Information

    • DRAMP ID

    • DRAMP00250

    • Peptide Name

    • Bacteriocin serracin-P 43 kDa subunit (Bacteriocin)

    • Source

    • Serratia plymuthica (Gram-negative bacteria)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DYHHGVRVL

    • Sequence Length

    • 9

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Erwinia amylovora.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00250 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00250.

Physicochemical Information

    • Formula

    • C49H74N16O13

    • Absent Amino Acids

    • ACEFIKMNPQSTW

    • Common Amino Acids

    • HV

    • Mass

    • 1095.23

    • PI

    • 6.92

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -19.16

    • Hydrophobicity

    • -0.433

    • Aliphatic Index

    • 107.78

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 186.25

    • Polar Residues

    • 2

DRAMP00250

Comments Information

    • Function

    • Major component of a prophage tail sheath. Antibacterial activity against Gram-negative bacteria E.amylovora.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of serracin P, a phage-tail-like bacteriocin, and its activity against Erwinia amylovora, the fire blight pathogen.

    • Reference

    • Appl Environ Microbiol. 2002 Nov;68(11):5704-5710.

    • Author

    • Jabrane A, Sabri A, Comp¨re P, Jacques P, Vandenberghe I, Van Beeumen J, Thonart P.