• • DRAMP ID

  • DRAMP00276

• • Peptide Name

  • Snakin-2 (StSN2; Cys-rich; Plant defensin)

• • Source

  • Solanum tuberosum (Potato)

• • Family

  • Not found

• • Gene

  • SN2

• • Sequence

  • YSYKKIDCGGACAARCRLSSRPRLCNRACGTCCARCNCVPPGTSGNTETCPCYASLTTHGNKRKCP

• • Sequence Length

  • 66

• • UniProt Entry

  • Q93X17,A1YN11,Q948Z5

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

• • Target Organism

  • • Gram-positive bacteria: Clavibacter michiganensis (EC50=4 µM), Ralstonia solanacearum (EC50=15 µM).
    • Fungi: pathogens Rhizobium meliloti (EC50=8 µM), Botrytis cinerea (EC50=2 µM), Fusarium solani (EC50=2 µM), Fusarium culmorum (EC50=2 µM), Fusarium oxysporum f.sp. conglutinans (EC50=10 µM), Fusarium oxysporum f.sp.lycopersici (EC50=20 µM), Plectosphaerella cucumerina (EC50=10 µM), Colletotrichum graminicola (EC50=10 µM), Colletotrichum lagenarium (EC50=10 µM), Bipolaris maydis (EC50=20 µM), Aspergillus flavus (EC50=20 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Bridge

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP00276.

DRAMP00276

• • Function

  • Has an antimicrobial activity. Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria.

• • Tissue specificity

  • Expressed in tubers, stems, flowers, shoot apex and leaves, but not in roots or stolons.

• • Induction

  • Locally up-regulated by abscisic acid, wounding and infection with compatible fungus. Down-regulated by gibberellic acid or infection with virulent bacteria. No responses to ethylene or abiotic stresses.

• • PTM

  • Six disulfide bonds may be present.

• ·Literature 1

• • Title

  • Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection.

• • Pubmed ID

  • 11891250

• • Reference

  • Plant Physiol. 2002 Mar;128(3):951-961.

• • Author

  • Marta Berrocal-Lobo, Ana Segura, Manuel Moreno, Gemma López, Francisco García-Olmedo, Antonio Molina