General Information

    • DRAMP ID

    • DRAMP00278

    • Peptide Name

    • Antifungal protein J (AFP-J; Plants)

    • Source

    • Solanum tuberosum (Potato)

    • Family

    • Belongs to the protease inhibitor I3

    • Gene

    • Not found

    • Sequence

    • LPSDATLVLDQTGKELDARL

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • [Ref.16076139]Fungi: Candida albicans TIMM 1768(MIC=6.25μg/mL)), Saccharomyces cerevisiae KCTC 7296(MIC=6.25μg/mL)), Trichosporon beigelii KCTC 7707(MIC=6.25μg/mL))

    • Hemolytic Activity

      • [Ref:16076139]Non-hemolytic activity against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00278 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00278.

Physicochemical Information

    • Formula

    • C93H159N25O33

    • Absent Amino Acids

    • CFHIMNWY

    • Common Amino Acids

    • L

    • Mass

    • 2155.43

    • PI

    • 4.23

    • Basic Residues

    • 2

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 8

    • Net Charge

    • -2

    • Boman Index

    • -34.32

    • Hydrophobicity

    • -0.165

    • Aliphatic Index

    • 122

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP00278

DRAMP00278 chydropathy plot

Comments Information

    • Function

    • Inhibitor of serine proteases chymotrypsin, pepsin and trypsin. Has strong antifungal activity. Non-hemolytic activity against human erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Kunitz-type serine protease inhibitor from potato (Solanum tuberosum L. cv. Jopung).

    • Reference

    • J Agric Food Chem. 2005 Aug 10;53(16):6491-6496.

    • Author

    • Park Y, Choi BH, Kwak JS, Kang CW, Lim HT, Cheong HS, Hahm KS.