• DRAMP ID

    • DRAMP00290
    • Peptide Name

    • Defensin Lc-def (Plant defensin)
    • Source

    • Lens culinaris subsp. culinaris (Cultivated lentil) (Lens esculenta)
    • Family

    • Belongs to the DEFL family
    • Gene

    • Unknown
    • Sequence

    • KTCENLSDSFKGPCIPDGNCNKHCKEKEHLLSGRCRDDFRCWCTRNC
    • Sequence Length

    • 47
    • Evidence code

    • Protein level
    • Biological Activity

    • Antifungal
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Combine helix and strand structure
    • Structure Description

    • Unknown
    • PDB ID

    • 2LJ7 resolved by NMR.
    • DRAMP00290 helical wheel diagram
    • Formula

    • C223H353N73O71S8
    • Absent Amino Acids

    • AMQVY
    • Common Amino Acids

    • C
    • Mass

    • 6269.87
    • PI

    • 7.98
    • Basic Residues

    • 11
    • Acidic Residues

    • 7
    • Hydrophobic Residues

    • 7
    • Boman Index

    • -152.93
    • Hydrophobicity

    • -106.38
    • Aliphatic Index

    • 33.19
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 6000
    • Absorbance 280nm

    • 130.43
    • Polar Residues

    • 20

DRAMP00290

DRAMP00290 chydropathy plot
    • Function

    • Has antifungal activity against the phytopathogenic fungus Aspergillus niger VKM F-2259, but not against A.alternatia VKM F- 3047. Does not inhibit trypsin or chymotrypsin.
    • PTM

    • Contains four disulfide bonds (By similarity).
  • Literature 1
    • Reference

    • Biochem Biophys Res Commun. 2008 Jul 11;371(4):860-865.
    • Author

    • Finkina EI, Shramova EI, Tagaev AA, Ovchinnikova TV.
    • Title

    • A novel defensin from the lentil Lens culinaris seeds.
  • Literature 2
    • Reference

    • To be Published.
    • Author

    • Shenkarev Z, Mineev K, Gizatullina A, Finkina E, Arseniev A, Ovchinnikova T.
    • Title

    • Solution structure of defensin Lc-def from germinated lentil (Lens Culinaris) seeds.