• DRAMP ID

    • DRAMP00299
    • Peptide Name

    • Ribonuclease (Plants)
    • Source

    • Thelephora ganbajun (Mushroom)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • DADIAVWAPPVNAQN
    • Sequence Length

    • 15
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antiviral
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00299 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00299.
    • Formula

    • C70H105N19O23
    • Absent Amino Acids

    • CEFGHKLMRSTY
    • Common Amino Acids

    • A
    • Mass

    • 1580.72
    • PI

    • 3.56
    • Basic Residues

    • 0
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 8
    • Net Charge

    • -2
    • Boman Index

    • -13.69
    • Hydrophobicity

    • -0.1
    • Aliphatic Index

    • 91.33
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 392.86
    • Polar Residues

    • 2

DRAMP00299

    • Function

    • Inhibits HIV-1 reverse transcriptase.
    • Miscellaneous

    • Inhibits HIV-1 reverse transcriptase with an IC50 of 300 nM.
    • Biophysicochemical properties

    • pH dependence (Optimum pH is 6-7); Temperature dependence (Optimum temperature is 45 degrees Celsius. Activity decreases sharply above 50 degrees Celsius and below 40 degrees Celsius).
  • ·Literature 1
    • Title

    • Purification of a novel ribonuclease from dried fruiting bodies of the edible wild mushroom Thelephora ganbajun.
    • Reference

    • Biochem Biophys Res Commun. 2004 Nov 12;324(2):855-859.
    • Author

    • Wang HX, Ng TB.