General Information

    • DRAMP ID

    • DRAMP00299

    • Peptide Name

    • Ribonuclease (Plants)

    • Source

    • Thelephora ganbajun (Mushroom)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DADIAVWAPPVNAQN

    • Sequence Length

    • 15

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00299 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00299.

Physicochemical Information

    • Formula

    • C70H105N19O23

    • Absent Amino Acids

    • CEFGHKLMRSTY

    • Common Amino Acids

    • A

    • Mass

    • 1580.72

    • PI

    • 3.56

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • -2

    • Boman Index

    • -13.69

    • Hydrophobicity

    • -0.1

    • Aliphatic Index

    • 91.33

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 2

DRAMP00299

Comments Information

    • Function

    • Inhibits HIV-1 reverse transcriptase.

    • Miscellaneous

    • Inhibits HIV-1 reverse transcriptase with an IC50 of 300 nM.

    • Biophysicochemical properties

    • pH dependence (Optimum pH is 6-7); Temperature dependence (Optimum temperature is 45 degrees Celsius. Activity decreases sharply above 50 degrees Celsius and below 40 degrees Celsius).

Literature Information

  • ·Literature 1

    • Title

    • Purification of a novel ribonuclease from dried fruiting bodies of the edible wild mushroom Thelephora ganbajun.

    • Reference

    • Biochem Biophys Res Commun. 2004 Nov 12;324(2):855-859.

    • Author

    • Wang HX, Ng TB.