General Information
-
DRAMP ID
- DRAMP00299
-
Peptide Name
- Ribonuclease (Plants)
-
Source
- Thelephora ganbajun (Mushroom)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- DADIAVWAPPVNAQN
-
Sequence Length
- 15
-
UniProt Entry
- P84784
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00299.
Physicochemical Information
-
Formula
- C70H105N19O23
Absent Amino Acids
- CEFGHKLMRSTY
Common Amino Acids
- A
Mass
- 1580.72
PI
- 3.56
Basic Residues
- 0
Acidic Residues
- 2
Hydrophobic Residues
- 8
Net Charge
- -2
-
Boman Index
- -13.69
Hydrophobicity
- -0.1
Aliphatic Index
- 91.33
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 392.86
Polar Residues
- 2
DRAMP00299
Comments Information
Function
- Inhibits HIV-1 reverse transcriptase.
Miscellaneous
- Inhibits HIV-1 reverse transcriptase with an IC50 of 300 nM.
Biophysicochemical properties
- pH dependence (Optimum pH is 6-7); Temperature dependence (Optimum temperature is 45 degrees Celsius. Activity decreases sharply above 50 degrees Celsius and below 40 degrees Celsius).
Literature Information
- ·Literature 1
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Title
- Purification of a novel ribonuclease from dried fruiting bodies of the edible wild mushroom Thelephora ganbajun.
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Pubmed ID
- 15474506
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Reference
- Biochem Biophys Res Commun. 2004 Nov 12;324(2):855-859.
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Author
- Wang HX, Ng TB.