• DRAMP ID

    • DRAMP00299
    • Peptide Name

    • Ribonuclease (Plants)
    • Source

    • Thelephora ganbajun (Mushroom)
    • Family

    • Unknown
    • Gene

    • Unknown
    • Sequence

    • DADIAVWAPPVNAQN
    • Sequence Length

    • 15
    • Evidence code

    • Protein level
    • Biological Activity

    • Antiviral, Antimicrobial
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknown
    • DRAMP00299 helical wheel diagram
    • Formula

    • C70H105N19O23
    • Absent Amino Acids

    • CEFGHKLMRSTY
    • Common Amino Acids

    • A
    • Mass

    • 1830.64
    • PI

    • 3.49
    • Basic Residues

    • 0
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 8
    • Boman Index

    • -13.69
    • Hydrophobicity

    • -10
    • Aliphatic Index

    • 91.33
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 392.86
    • Polar Residues

    • 2

DRAMP00299

    • Function

    • Inhibits HIV-1 reverse transcriptase.
    • Miscellaneous

    • Inhibits HIV-1 reverse transcriptase with an IC50 of 300 nM.
    • Biophysicochemical properties

    • pH dependence (Optimum pH is 6-7); Temperature dependence (Optimum temperature is 45 degrees Celsius. Activity decreases sharply above 50 degrees Celsius and below 40 degrees Celsius).
  • Literature 1
    • Reference

    • Biochem Biophys Res Commun. 2004 Nov 12;324(2):855-859.
    • Author

    • Wang HX, Ng TB.
    • Title

    • Purification of a novel ribonuclease from dried fruiting bodies of the edible wild mushroom Thelephora ganbajun.