General Information

    • DRAMP ID

    • DRAMP00322

    • Peptide Name

    • Insecticidal protein LA-a (Latex abundant protein a; Plant defensin)

    • Source

    • Morus alba (White mulberry)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SEPQXGRDAGGAL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Insecticidal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Chitin-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00322 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00322.

Physicochemical Information

    • Formula

    • C46H74N16O18

    • Absent Amino Acids

    • CFHIKMNTVWY

    • Common Amino Acids

    • G

    • Mass

    • 1268.54

    • PI

    • 4.37

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 3

    • Net Charge

    • -1

    • Boman Index

    • -28.03

    • Hydrophobicity

    • -0.862

    • Aliphatic Index

    • 45.38

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP00322

Comments Information

    • Function

    • Has insecticidal activity when consumed by D. melanogaster larvae. Has low chitinase and chitosanase activity.

    • Catalytic activity

    • Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. Endohydrolysis of beta-(1->4)-linkages between D-glucosamine residues in a partly acetylated chitosan.

    • PTM

    • Glycosylated; contains galactose.

Literature Information

  • ·Literature 1

    • Title

    • Two chitinase-like proteins abundantly accumulated in latex of mulberry show insecticidal activity.

    • Reference

    • BMC Biochem. 2010 Jan 28;11:6.

    • Author

    • Kitajima S, Kamei K, Taketani S, Yamaguchi M, Kawai F, Komatsu A, Inukai Y.