General Information

    • DRAMP ID

    • DRAMP00370

    • Peptide Name

    • Antifungal protein 5 (CW-5; Plants)

    • Source

    • Malva parviflora (Little mallow) (Cheeseweed mallow)

    • Family

    • Belongs to the plant LTP family

    • Gene

    • Not found

    • Sequence

    • ITCGQVTSQVAGCLSYLQRGGAPAPXXXXGIRNLXXMA

    • Sequence Length

    • 38

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Fusarium graminearum.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00370 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00370.

Physicochemical Information

    • Formula

    • C137H218N42O36S3

    • Absent Amino Acids

    • DEFHKW

    • Common Amino Acids

    • X

    • Mass

    • 0

    • PI

    • 0

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • -15.65

    • Hydrophobicity

    • 0.274

    • Aliphatic Index

    • 77.11

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1615

    • Absorbance 280nm

    • 43.65

    • Polar Residues

    • 13

DRAMP00370

DRAMP00370 chydropathy plot

Comments Information

    • Function

    • Possesses potent antifungal activity against F. graminearum but not P. infestans.

    • Miscellaneous

    • Under low salt conditions, possesses potent antifungal activity but activity is drastically reduced under high salt conditions.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of three antifungal proteins from cheeseweed (Malva parviflora).

    • Reference

    • Biochem Biophys Res Commun. 2001 Apr 20;282(5):1224-1228.

    • Author

    • Wang X, Bunkers GJ, Walters MR, Thoma RS.