General Information
-
DRAMP ID
- DRAMP00380
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Peptide Name
- Antifungal protein 4 (CW-4; Plants)
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Source
- Malva parviflora (Little mallow) (Cheeseweed mallow)
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Family
- Not found
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Gene
- Not found
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Sequence
- DRQIDMEEQQLEKLNKQDRXPGLRYAAKQQMXTXRMG
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Sequence Length
- 37
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UniProt Entry
- P83138
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
-
- Fungi: Phytophthora infestans.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00380.
Physicochemical Information
-
Formula
- C170H280N56O53S3
Absent Amino Acids
- CFHSVW
Common Amino Acids
- Q
Mass
- 4440.65
PI
- 8.43
Basic Residues
- 7
Acidic Residues
- 6
Hydrophobic Residues
- 6
Net Charge
- +1
-
Boman Index
- -133.28
Hydrophobicity
- -1.47
Aliphatic Index
- 47.57
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 41.39
Polar Residues
- 5
DRAMP00380
Comments Information
Function
- Possesses antifungal activity.
Miscellaneous
- Antimicrobial activity is not affected by salt concentration.
Biophysicochemical properties
- Temperature dependence (Thermostable). Still active after heating at 100 degrees Celsius for 20 minutes.
Literature Information
- ·Literature 1
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Title
- Purification and characterization of three antifungal proteins from cheeseweed (Malva parviflora).
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Pubmed ID
- 11302747
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Reference
- Biochem Biophys Res Commun. 2001 Apr 20;282(5):1224-1228.
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Author
- Wang X, Bunkers GJ, Walters MR, Thoma RS.