General Information

    • DRAMP ID

    • DRAMP00385

    • Peptide Name

    • Panitide L2 (plants)

    • Source

    • Panicum laxum

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • QLPICGETCVLGGCYTPNCRCQYPICVR

    • Sequence Length

    • 28

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=2.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.23195955] IC50 = 6.0 μM against HeLa cells.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Pyroglutamyl modification

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • There are three disulfide bonds in the peptide structure

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00385 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00385.

Physicochemical Information

    • Formula

    • C130H209N37O38S6

    • Absent Amino Acids

    • ADFHKMSW

    • Common Amino Acids

    • C

    • Mass

    • 3090.67

    • PI

    • 7.77

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • -21.53

    • Hydrophobicity

    • 0.25

    • Aliphatic Index

    • 76.43

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 124.26

    • Polar Residues

    • 14

DRAMP00385

DRAMP00385 chydropathy plot

Comments Information

    • PTM

    • N-terminus is a pyruglutamyl.

Literature Information

  • ·Literature 1

    • Title

    • Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants.

    • Reference

    • J Biol Chem. 2013 Feb 1;288(5):3370-3380.

    • Author

    • Nguyen GK, Lian Y, Pang EW, Nguyen PQ, Tran TD, Tam JP.