General Information

    • DRAMP ID

    • DRAMP00388

    • Peptide Name

    • Antimicrobial peptide 2 (EcAMP2; Plants)

    • Source

    • Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DRCSQQCQHHRDPDRKQQCMRECRRHQGRSD

    • Sequence Length

    • 31

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Phytophthora infestans (IC50=24 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00388 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00388.

Physicochemical Information

    • Formula

    • C147H243N65O50S5

    • Absent Amino Acids

    • AFILNTVWY

    • Common Amino Acids

    • R

    • Mass

    • 3881.25

    • PI

    • 8.98

    • Basic Residues

    • 11

    • Acidic Residues

    • 5

    • Hydrophobic Residues

    • 0

    • Net Charge

    • +6

    • Boman Index

    • -197.29

    • Hydrophobicity

    • -2.426

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 8.33

    • Polar Residues

    • 7

DRAMP00388

DRAMP00388 chydropathy plot

Comments Information

    • Function

    • EcAMP2 inhibits spore germination of P. infestans with an IC50 of 24 µM but have no antibacterial activity.

    • PTM

    • Contains two disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Defense peptides from barnyard grass (Echinochloa crusgalli L.) seeds.

    • Reference

    • Peptides. 2012 Nov;38(1):33-40.

    • Author

    • Rogozhin EA, Ryazantsev DY, Grishin EV, Egorov TA, Zavriev SK.