General Information
-
DRAMP ID
- DRAMP00389
-
Peptide Name
- EcAMP2.1 (truncated EcAMP2 without five C-terminal residues)
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Source
- Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- DRCSQQCQHHRDPDRKQQCMRECRRH
-
Sequence Length
- 26
-
UniProt Entry
- B3EWR4
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Phytophthora infestans (IC50=24 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00389.
Physicochemical Information
-
Formula
- C127H210N56O41S5
Absent Amino Acids
- AFGILNTVWY
Common Amino Acids
- R
Mass
- 3337.72
PI
- 8.98
Basic Residues
- 10
Acidic Residues
- 4
Hydrophobic Residues
- 0
Net Charge
- +6
-
Boman Index
- -165.65
Hydrophobicity
- -2.404
Aliphatic Index
- 0
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 250
Absorbance 280nm
- 10
Polar Residues
- 5
DRAMP00389
Comments Information
Function
- EcAMP2.1 inhibits spore germination of P. infestans with an IC50 of 24 µM but have no antibacterial activity.
PTM
- Contains two disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Defense peptides from barnyard grass (Echinochloa crusgalli L.) seeds.
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Pubmed ID
- 22940285
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Reference
- Peptides. 2012 Nov;38(1):33-40.
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Author
- Rogozhin EA, Ryazantsev DY, Grishin EV, Egorov TA, Zavriev SK.