General Information
-
DRAMP ID
- DRAMP00390
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Peptide Name
- Antimicrobial peptide 3 (ToAMP3; Cys-rich; Plant defensin)
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Source
- Taraxacum officinale (Common dandelion) (Leontodon taraxacum)
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Family
- Not found
-
Gene
- Not found
-
Sequence
- ANKCIIDCMKVKTTCGDECKGAGFKTGGCALPPDIMKCCHNC
-
Sequence Length
- 42
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UniProt Entry
- B3EWQ3
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
-
- Fungi: Aspergillus niger (IC50=1.2 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00390.
Physicochemical Information
-
Formula
- C180H300N52O56S10
Absent Amino Acids
- QRSWY
Common Amino Acids
- C
Mass
- 4409.28
PI
- 8.21
Basic Residues
- 7
Acidic Residues
- 4
Hydrophobic Residues
- 9
Net Charge
- +3
-
Boman Index
- -40.15
Hydrophobicity
- -0.033
Aliphatic Index
- 51.19
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 500
Absorbance 280nm
- 12.2
Polar Residues
- 18
DRAMP00390
Comments Information
Function
- Possesses antifungal activity. Also active against bacterial species P. syringae, B. subtilis and X. campestris.
Tissue specificity
- Expressed in flowers but not in leaves, seeds or roots (at protein level).
Literature Information
- ·Literature 1
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Title
- Discovery of novel antimicrobial peptides with unusual cysteine motifs in dandelion Taraxacum officinale Wigg. flowers.
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Pubmed ID
- 22640720
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Reference
- Peptides. 2012 Aug;36(2):266-271.
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Author
- Astafieva AA, Rogozhin EA, Odintsova TI, Khadeeva NV, Grishin EV, Egorov TsA.