General Information
-
DRAMP ID
- DRAMP00391
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Peptide Name
- Antimicrobial peptide 2 (ToAMP2; Cys-rich; Plant defensin)
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Source
- Taraxacum officinale (Common dandelion) (Leontodon taraxacum)
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Family
- Not found
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Gene
- Not found
-
Sequence
- GGKCTVDWGGQGGGRRLPSPLFCCYKPTRICYLNQETCETETCP
-
Sequence Length
- 44
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UniProt Entry
- B3EWQ2
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
-
- Fungi: Botrytis cinerea (IC50=5.2 µM), Aspergillus niger (IC50=2.6 µM), Bipolaris sorokiniana (IC50=5.2 µM), Pythium debaryanum (IC50=2.6 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00391.
Physicochemical Information
-
Formula
- C205H319N59O64S6
Absent Amino Acids
- AHM
Common Amino Acids
- G
Mass
- 4826.5
PI
- 7.77
Basic Residues
- 5
Acidic Residues
- 4
Hydrophobic Residues
- 7
Net Charge
- +1
-
Boman Index
- -75.97
Hydrophobicity
- -0.566
Aliphatic Index
- 42.05
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8855
Absorbance 280nm
- 205.93
Polar Residues
- 22
DRAMP00391
Comments Information
Function
- Possesses antifungal activity. Also active against bacterial species P. syringae, B. subtilis and X. campestris.
Tissue specificity
- Expressed in flowers but not in leaves, seeds or roots (at protein level).
Literature Information
- ·Literature 1
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Title
- Discovery of novel antimicrobial peptides with unusual cysteine motifs in dandelion Taraxacum officinale Wigg. flowers.
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Pubmed ID
- 22640720
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Reference
- Peptides. 2012 Aug;36(2):266-271.
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Author
- Astafieva AA, Rogozhin EA, Odintsova TI, Khadeeva NV, Grishin EV, Egorov TsA.