General Information
-
DRAMP ID
- DRAMP00393
-
Peptide Name
- Hedyotide B2 (hB2; Uncyclotides; Plants)
-
Source
- Hedyotis biflora (aerial tissues)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- IQCGESCVWIPCISSAWGCSCKNKICSS
-
Sequence Length
- 28
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacterium: Escherichia coli (MIC>80 µM);
- Gram-positive bacteria: Streptococcus salivarius(MIC>80 µM), Staphylococcus epidermidis (MIC>80 µM), Streptococcus aureus (MIC>80 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00393.
Physicochemical Information
-
Formula
- C125H198N34O39S6
Absent Amino Acids
- DFHLMRTY
Common Amino Acids
- CS
Mass
- 2993.51
PI
- 7.77
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- -10.74
Hydrophobicity
- 0.418
Aliphatic Index
- 69.64
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11375
Absorbance 280nm
- 421.3
Polar Residues
- 15
DRAMP00393
Comments Information
Function
- Possesses antifungal activity.
Literature Information
- ·Literature 1
-
Title
- Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry.
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Pubmed ID
- 21979955
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Reference
- J Biol Chem. 2011 Dec 30;286(52):44833-44844.
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Author
- Nguyen GK, Zhang S, Wang W, Wong CT, Nguyen NT, Tam JP.