General Information

    • DRAMP ID

    • DRAMP00405

    • Peptide Name

    • Defensin D4 (So-D4; Antimicrobial peptide D4; Plant defensin)

    • Source

    • Spinacia oleracea (Spinach)

    • Family

    • Belongs to the DEFL family

    • Gene

    • Not found

    • Sequence

    • MFFSSKKCKTVSKTFRGPCVRNA

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

      • Fungi: Fusarium spp.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00405 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00405.

Physicochemical Information

    • Formula

    • C115H188N34O30S3

    • Absent Amino Acids

    • DEHILQWY

    • Common Amino Acids

    • K

    • Mass

    • 2623.15

    • PI

    • 10.48

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +6

    • Boman Index

    • -49.34

    • Hydrophobicity

    • -0.365

    • Aliphatic Index

    • 29.57

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 5.68

    • Polar Residues

    • 9

DRAMP00405

DRAMP00405 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens.

    • Tissue specificity

    • Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots.

    • Developmental stage

    • Present throughout the life of the leaf.

Literature Information

  • ·Literature 1

    • Title

    • Novel defensin subfamily from spinach (Spinacia oleracea).

    • Reference

    • FEBS Lett. 1998; 435: 159-162.

    • Author

    • Segura A, Moreno M, Molina A, Garcia-Olmedo F.