• • DRAMP ID

  • DRAMP00407

• • Peptide Name

  • Defensin D6 (So-D6; Antimicrobial peptide D6; Plant defensin)

• • Source

  • Spinacia oleracea (Spinach)

• • Family

  • Belongs to the DEFL family

• • Gene

  • Not found

• • Sequence

  • GIFSNMYXRTPAGYFRGPXGYXXN

• • Sequence Length

  • 24

• • UniProt Entry

  • P81567

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-positive bacterium: Clavibacter michiganensis (EC50=1 µM);
    • Gram-negative bacterium: Ralstonia solanacearum (EC50=6 µM).
    • Fungi: Fusarium solani (EC50=11 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP00407.

DRAMP00407

• • Function

  • Antimicrobial peptide. Active against Fusarium spp., Gram-positive and Gram-negative bacterial pathogens.

• • Tissue specificity

  • Distributed in the epidermal cell layer of leaves and in the subepidermal layer region of stems. Not in roots.

• • Developmental stage

  • Present throughout the life of the leaf.

• ·Literature 1

• • Title

  • Novel defensin subfamily from spinach (Spinacia oleracea).

• • Pubmed ID

  • 9762899

• • Reference

  • FEBS Lett. 1998; 435: 159-162.

• • Author

  • Segura A, Moreno M, Molina A, Garcia-Olmedo F.