General Information

    • DRAMP ID

    • DRAMP00409

    • Peptide Name

    • Defensin-like protein (Sesquin; Plant defensin)

    • Source

    • Vigna unguiculata subsp. sesquipedalis (Yard-Long bean)

    • Family

    • Belongs to the DEFL family

    • Gene

    • Not found

    • Sequence

    • KTCENLADTY

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal

    • Target Organism

      • Fungi: Botrytis cinerea (IC50=2.5±0.01 µM), Fusarium oxysporum (IC50=1.4±0.02 µM), Mycosphaerella arachidicola (IC50=0.15±0.002 µM).
      • Gram-positive bacteria: Bacillus megaterium, Mycobacterium phlei;
      • Gram-negative bacteria: Escherichia coli, Proteus vulgaris.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00409 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00409.

Physicochemical Information

    • Formula

    • C48H76N12O19S

    • Absent Amino Acids

    • FGHIMPQRSVW

    • Common Amino Acids

    • T

    • Mass

    • 1157.26

    • PI

    • 4.37

    • Basic Residues

    • 1

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 2

    • Net Charge

    • -1

    • Boman Index

    • -24.99

    • Hydrophobicity

    • -0.9

    • Aliphatic Index

    • 49

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 165.56

    • Polar Residues

    • 5

DRAMP00409

Comments Information

    • Function

    • Has antifungal and antibacterial activity. Has mitogenic activity towards murine splenocytes. Inhibits the proliferation of M1 leukemia and MCF-7 breast cancer cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase.

Literature Information

  • ·Literature 1

    • Title

    • Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase.

    • Reference

    • Peptides. 2005 Jul;26(7):1120-1126.

    • Author

    • Wong JH, Ng TB