General Information
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Alternaria brassicola (IC50=3 µg/ml), Botrytis cinerea (IC50=1.50 µg/ml), Fusarium culmorum (IC50=2 µg/ml), Fusarium oxysporum f.sp.lycopersici (IC50=1.80 µg/ml), Pyricularia oryzae (IC50=0.25 µg/ml), Verticiliium dahliae (IC50=0.80 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Rich
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- 1AYJ
- 1AYJ-> 
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Predicted Structure
- There is no predicted structure for DRAMP00410.
Physicochemical Information
-
Formula
- C204H321N67O62S5
Absent Amino Acids
- DM
Common Amino Acids
- N
Mass
- 4864.5
PI
- 9.02
Basic Residues
- 8
Acidic Residues
- 2
Hydrophobic Residues
- 10
Net Charge
- +6
-
Boman Index
- -95.07
Hydrophobicity
- -0.793
Aliphatic Index
- 46.59
Half Life
-
- Mammalian:0.8 hour
- Yeast:10 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7240
Absorbance 280nm
- 168.37
Polar Residues
- 20
DRAMP00410
Comments Information
Function
- Possesses antifungal activity sensitive to inorganic cations.
Subunit structure
- Forms oligomers in its native state.
PTM
- Problely contains one disulfide bond.
Literature Information
- ·Literature 1
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Title
- A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species.
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Pubmed ID
- 8422949
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Reference
- FEBS Lett. 1993 Feb 1;316(3):233-240.
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Author
- Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF.