• DRAMP ID

    • DRAMP00419
    • Peptide Name

    • Hc-AFP3 (Plant defensin)
    • Source

    • Heliophila coronopifolia (South African Brassicaceae species)
    • Family

    • Not found
    • Gene

    • Hc-AFP3
    • Sequence

    • RYCERSSGTWSGVCGNTDKCSSQCQRLEGAAHGSCNYVFPAHKCICYYPC
    • Sequence Length

    • 50
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antifungal
    • Target Organism

      • Fungi: Botrytis cinerea (IC50=20-25 µg/ml), Fusarium solani (IC50>25 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00419 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00419.
    • Formula

    • C231H346N70O73S8
    • Absent Amino Acids

    • M
    • Common Amino Acids

    • C
    • Mass

    • 5528.19
    • PI

    • 8.2
    • Basic Residues

    • 7
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +4
    • Boman Index

    • -94.38
    • Hydrophobicity

    • -0.496
    • Aliphatic Index

    • 33.2
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 11960
    • Absorbance 280nm

    • 244.08
    • Polar Residues

    • 27

DRAMP00419

DRAMP00419 chydropathy plot
    • Function

    • Has antifungal activity.
    • PTM

    • Contains four disulfide bonds.
  • ·Literature 1
    • Title

    • Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes.
    • Reference

    • BMC Res Notes. 2011 Oct 28;4:459.
    • Author

    • de Beer A, Vivier MA.