General Information
-
DRAMP ID
- DRAMP00421
-
Peptide Name
- Hc-AFP1 (Plant defensin)
-
Source
- Heliophila coronopifolia (South African Brassicaceae species)
-
Family
- Not found
-
Gene
- Hc-AFP1
-
Sequence
- RYCERSSGTWSGVCGNSGKCSNQCQRLEGAAHGSCNYVFPAHKCICYYPC
-
Sequence Length
- 50
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
-
- Fungi: Botrytis cinerea (IC50>25 µg/ml), Fusarium solani (IC50>25 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00421.
Physicochemical Information
-
Formula
- C229H343N71O71S8
Absent Amino Acids
- DM
Common Amino Acids
- C
Mass
- 5483.16
PI
- 8.5
Basic Residues
- 7
Acidic Residues
- 2
Hydrophobic Residues
- 9
Net Charge
- +5
-
Boman Index
- -88.79
Hydrophobicity
- -0.49
Aliphatic Index
- 33.2
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 11960
Absorbance 280nm
- 244.08
Polar Residues
- 28
DRAMP00421
Comments Information
Function
- Has antifungal activity.
PTM
- Contains four disulfide bonds.
Literature Information
- ·Literature 1
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Title
- Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes.
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Pubmed ID
- 22032337
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Reference
- BMC Res Notes. 2011 Oct 28;4:459.
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Author
- de Beer A, Vivier MA.