General Information

    • DRAMP ID

    • DRAMP00474

    • Peptide Name

    • Defensin-like protein 18 (Plant defensin 1.5; Plant defensin)

    • Source

    • Arabidopsis thaliana (Mouse-ear cress)

    • Family

    • Belongs to the DEFL family

    • Gene

    • PDF1.5

    • Sequence

    • LCKRESETWSGRCVNDYQCRDHCINNDRGNDGYCAGGYPWYRSCFCFFSC

    • Sequence Length

    • 50

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00474 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00474.

Physicochemical Information

    • Formula

    • C249H355N75O77S8

    • Absent Amino Acids

    • M

    • Common Amino Acids

    • C

    • Mass

    • 5887.49

    • PI

    • 6.7

    • Basic Residues

    • 7

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • -137.91

    • Hydrophobicity

    • -0.798

    • Aliphatic Index

    • 23.4

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 17460

    • Absorbance 280nm

    • 356.33

    • Polar Residues

    • 26

DRAMP00474

DRAMP00474 chydropathy plot

Comments Information

    • Function

    • Confers broad-spectrum resistance to pathogens.

    • PTM

    • Contains four disulfide bonds 3-51; 14-35; 20-45; 24-47.

Literature Information

  • ·Literature 1

    • Title

    • Genome organization of more than 300 defensin-like genes in Arabidopsis.

    • Reference

    • Plant Physiol. 2005 Jun;138(2):600-610.

    • Author

    • Silverstein KA, Graham MA, Paape TD, VandenBosch KA.
  • ·Literature 2

    • Title

    • Plant defensins.

    • Reference

    • Planta. 2002 Dec;216(2):193-202.

    • Author

    • Thomma BP, Cammue BP, Thevissen K.