General Information

    • DRAMP ID

    • DRAMP00753

    • Peptide Name

    • Elicitor peptide 1 (AtPep1; Plant defensin)

    • Source

    • Arabidopsis thaliana (Mouse-ear cress)

    • Family

    • Belongs to the brassicaceae elicitor peptide family

    • Gene

    • PEP1

    • Sequence

    • ATKVKAKQRGKEKVSSGRPGQHN

    • Sequence Length

    • 23

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • Pythium irregulare

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Sequential removal of N-terminal amino acids has little effect on activity. Activity is completely abolished when nine C-terminal amino acids remained. Removal of the C-terminal asparagine from AtPep1(9-23), resultes in a decrease in activity (12 max approximately 100 nM).

    • Helical Wheel Diagram

    • DRAMP00753 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00753.

Physicochemical Information

    • Formula

    • C104H183N39O32

    • Absent Amino Acids

    • CDFILMWY

    • Common Amino Acids

    • K

    • Mass

    • 2491.84

    • PI

    • 11.22

    • Basic Residues

    • 8

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +7

    • Boman Index

    • -81.63

    • Hydrophobicity

    • -1.687

    • Aliphatic Index

    • 33.91

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP00753

DRAMP00753 chydropathy plot

Comments Information

    • Function

    • Elicitor of plant defense. Induces the production of plant defensin (PDF1.2) and of H2O2. Promotes resistance to the root fungal pathogen P. irregulare.

    • Subunit structure

    • Interacts with its receptor PEPR1.

    • Induction

    • By wounding, methyl jasmonate (MeJA), ethylene. The expression of the peptide PEP1 precursor is induced by the mature peptide PEP1.

Literature Information

  • ·Literature 1

    • Title

    • An endogenous peptide signal in Arabidopsis activates components of the innate immune response.

    • Reference

    • Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10098-103.

    • Author

    • Huffaker A, Pearce G, Ryan CA.
  • ·Literature 2

    • Title

    • The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells.

    • Reference

    • Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10104-9.

    • Author

    • The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells.
  • ·Literature 3

    • Title

    • Structure-activity studies of AtPep1, a plant peptide signal involved in the innate immune response.

    • Reference

    • Peptides. 2008 Dec;29(12):2083-9.

    • Author

    • Pearce G, Yamaguchi Y, Munske G, Ryan CA.