General Information
-
DRAMP ID
- DRAMP00764
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Peptide Name
- Piceain 1 (Plants)
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Source
- Picea sitchensis
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Family
- Not found
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Gene
- Not found
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Sequence
- KSLRPRCWIKIKFRCKSLKF
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Sequence Length
- 20
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Swiss_Prot Entry
- No entry found
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Evidence code
- Not found
Activity Information
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Biological Activity
- Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial
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Target Organism
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- Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 µg/ml), S. aureus ATCC 43300 (MIC=9.38 µg/ml);
- Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=18.75 µg/ml), Escherichia coli ML-35P (MIC=18.75 µg/ml), Escherichia coli 08040722 (CI) (MIC=75 µg/ml), Escherichia coli 08A866 (CI) (MIC=37.5 µg/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=9.38 µg/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 µg/ml).
- Yeast: Candida albicans ATCC 20032 (MIC=9.38 µg/ml).
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Hemolytic Activity
-
- Not found
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Beta strand (CD)
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Structure Description
- Not found
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PDB ID
- None
-
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Physicochemical Information
-
Formula
- C118H197N35O23S2
Absent Amino Acids
- ADEGHMNQTVY
Common Amino Acids
- K
Mass
- 2877.27
PI
- 11.78
Basic Residues
- 8
Acidic Residues
- 0
Hydrophobic Residues
- 7
-
Boman Index
- -48.78
Hydrophobicity
- -0.495
Aliphatic Index
- 78
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5625
Absorbance 280nm
- 296.05
Polar Residues
- 4
DRAMP00764

Comments Information
Function
- Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells.
PTM
- Contains one disulfide bond.
Literature Information
- ·Literature 1
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Title
- Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis.
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Pubmed ID
- 21644248
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Reference
- J Pept Sci. 2011 Sep;17(9):627-631.
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Author
- Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R.