General Information

    • DRAMP ID

    • DRAMP00764

    • Peptide Name

    • Piceain 1 (Plants)

    • Source

    • Picea sitchensis

    • Family

    • Unknown

    • Gene

    • Unknown

    • Sequence

    • KSLRPRCWIKIKFRCKSLKF

    • Sequence Length

    • 20

    • Swiss_Prot Entry

    • No entry found

    • Evidence code

    • Unknown

Activity Information

    • Biological Activity

    • Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-, Antimicrobial

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=9.38 µg/ml), S. aureus ATCC 43300 (MIC=9.38 µg/ml);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=18.75 µg/ml), Escherichia coli ML-35P (MIC=18.75 µg/ml), Escherichia coli 08040722 (CI) (MIC=75 µg/ml), Escherichia coli 08A866 (CI) (MIC=37.5 µg/ml), Pseudomonas aeruginosa PA01 (MIC=9.38 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=9.38 µg/ml), Pseudomonas aeruginosa 08031014 (CI) (MIC=37.5 µg/ml).
      • Yeast: Candida albicans ATCC 20032 (MIC=9.38 µg/ml).

    • Hemolytic activity

    • Unknown

    • Binding Target

    • Unknown

Structure Information

    • Structure

    • Beta strand (CD)

    • Structure Description

    • Unknown
    • DRAMP00764 helical wheel diagram

Physical Information

    • Formula

    • C118H197N35O23S2

    • Absent Amino Acids

    • ADEGHMNQTVY

    • Common Amino Acids

    • K

    • Mass

    • 2877.27

    • PI

    • 11.78

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Boman Index

    • -48.78

    • Hydrophobicity

    • -49.5

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 296.05

    • Polar Residues

    • 4

DRAMP00764

DRAMP00764 chydropathy plot

Comments Information

    • Function

    • Active against both Gram-postive and Gram-negative bacteria, fungi. It showed weak hemolysis activity against human and rabbit red cells.

    • PTM

    • Contains one disulfide bond.

Literature Information

  • Literature 1

    • Reference

    • J Pept Sci. 2011 Sep;17(9):627-631.

    • Author

    • Liu R, Mu L, Liu H, Wei L, Yan T, Chen M, Zhang K, Li J, You D, Lai R.

    • Title

    • Two antimicrobial and nematicidal peptides derived from sequences encoded Picea sitchensis.