• DRAMP ID

    • DRAMP00771
    • Peptide Name

    • Psyle A (Cyclotides; Plants)
    • Source

    • Psychotria leptothyrsa
    • Family

    • Belongs to the cyclotide family
    • Gene

    • Not found
    • Sequence

    • GIACGESCVFLGCFIPGCSCKSKVCYFN
    • Sequence Length

    • 28
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Anti-HIV, Anti-cancer
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • [Ref.20575512] Cytotoxicity: the human lymphoma cell line U-937 GTB (IC50 = 26 µM).
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • No specific N-terminal
    • C-terminal Modification

    • No specific C-terminal
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys I and CysIV, CysII and CysV, CysIII and CysVI .
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00771 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00771.
    • Formula

    • C128H195N31O36S6
    • Absent Amino Acids

    • DHMQRTW
    • Common Amino Acids

    • C
    • Mass

    • 2936.5
    • PI

    • 7.77
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +1
    • Boman Index

    • 10.14
    • Hydrophobicity

    • 0.882
    • Aliphatic Index

    • 66.07
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1865
    • Absorbance 280nm

    • 69.07
    • Polar Residues

    • 15

DRAMP00771

DRAMP00771 chydropathy plot
    • Function

    • Cyclotide cytotoxicity on the human lymphoma cell line U-937 GTB (IC50=26 µM).
  • ·Literature 1
    • Title

    • Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa.
    • Reference

    • J Nat Prod. 2010 Jul 23;73(7):1207-1213.
    • Author

    • Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U.