General Information

    • DRAMP ID

    • DRAMP00772

    • Peptide Name

    • Psyle C (uncyclotides; Plants)

    • Source

    • Psychotria leptothyrsa

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KLCGETCFKFKCYTPGCSCSYPFCK

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Anti-cancer

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00772 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00772.

Physicochemical Information

    • Formula

    • C126H187N29O34S6

    • Absent Amino Acids

    • ADHIMNQRVW

    • Common Amino Acids

    • C

    • Mass

    • 2844.4

    • PI

    • 8.64

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -17.81

    • Hydrophobicity

    • -0.06

    • Aliphatic Index

    • 15.6

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 139.79

    • Polar Residues

    • 14

DRAMP00772

DRAMP00772 chydropathy plot

Comments Information

    • Cyclotide cytotoxicity on the human lymphoma cell line U-937 GTB (IC50=3.5 µM).

Literature Information

  • ·Literature 1

    • Title

    • Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa.

    • Reference

    • J Nat Prod. 2010 Jul 23;73(7):1207-1213.

    • Author

    • Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U.