General Information
-
DRAMP ID
- DRAMP00773
-
Peptide Name
- Psyle E (Cyclotides; Plants)
-
Source
- Psychotria leptothyrsa
-
Family
- Belongs to the cyclotide family
-
Gene
- Not found
-
Sequence
- GVIPCGESCVFIPCISSVLGCSCKNKVCYRD
-
Sequence Length
- 31
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Anti-cancer
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- [Ref.20575512] Cytotoxicity: the human lymphoma cell line U-937 GTB (IC50=0.76 µM).
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- No specific N-terminal
-
C-terminal Modification
- No specific C-terminal
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys I and CysIV, CysII and CysV, CysIII and CysVI .
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00773.
Physicochemical Information
-
Formula
- C139H227N37O42S6
Absent Amino Acids
- AHMQTW
Common Amino Acids
- C
Mass
- 3280.91
PI
- 7.77
Basic Residues
- 3
Acidic Residues
- 2
Hydrophobic Residues
- 9
Net Charge
- +1
-
Boman Index
- -12.61
Hydrophobicity
- 0.652
Aliphatic Index
- 87.74
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 62.17
Polar Residues
- 15
DRAMP00773
Comments Information
Function
- Cyclotide cytotoxicity on the human lymphoma cell line U-937 GTB (IC50=0.76 µM).
Literature Information
- ·Literature 1
-
Title
- Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa.
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Pubmed ID
- 20575512
-
Reference
- J Nat Prod. 2010 Jul 23;73(7):1207-1213.
-
Author
- Gerlach SL, Burman R, Bohlin L, Mondal D, Göransson U.