General Information
-
DRAMP ID
- DRAMP00780
-
Peptide Name
- Viphi A (Plants)
-
Source
- Viola philippica
-
Family
- Belongs to the cyclotide family
-
Gene
- Not found
-
Sequence
- GSIPCGESCVFIPCISSVIGCACKSKVCYKN
-
Sequence Length
- 31
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Anti-cancer
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Target Organism
-
- Cancer cell lines: BGC-823 (IC50=1.75±0.05 µM), MM96L (IC50=4.91±0.04 µM), HeLa (IC50=15.5±0.06 µM).
- Non-cancer cell line: HFF-1 (IC50=3.19±0.01 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00780.
Physicochemical Information
-
Formula
- C136H223N35O41S6
Absent Amino Acids
- DHLMQRTW
Common Amino Acids
- C
Mass
- 3196.84
PI
- 8.33
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- +2
-
Boman Index
- -0.15
Hydrophobicity
- 0.703
Aliphatic Index
- 81.61
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 62.17
Polar Residues
- 16
DRAMP00780
Comments Information
Function
- The novel cyclotides show cytotoxic activity against several cancer cell lines.
Literature Information
- ·Literature 1
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Title
- Isolation and characterization of cytotoxic cyclotides from Viola philippica.
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Pubmed ID
- 21723349
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Reference
- Peptides. 2011 Aug;32(8):1719-1723.
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Author
- He W, Chan LY, Zeng G, Daly NL, Craik DJ, Tan N.