General Information
-
DRAMP ID
- DRAMP00813
-
Peptide Name
- Cycloviolacin-O10 (Plant defensin)
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Source
- Viola odorata (Sweet violet)
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Family
- Belongs to the cyclotide family
-
Gene
- Not found
-
Sequence
- GIPCGESCVYIPCLTSAVGCSCKSKVCYRN
-
Sequence Length
- 30
-
UniProt Entry
- P58442
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Insecticidal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
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N-terminal Modification
- No specific N-terminal
-
C-terminal Modification
- No specific C-terminal
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27.
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Stereochemistry
- L
-
Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00813.
Physicochemical Information
-
Formula
- C131H214N36O41S6
Absent Amino Acids
- DFHMQW
Common Amino Acids
- C
Mass
- 3141.72
PI
- 8.33
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 7
Net Charge
- +2
-
Boman Index
- -16.73
Hydrophobicity
- 0.4
Aliphatic Index
- 71.33
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 115.69
Polar Residues
- 17
DRAMP00813
Comments Information
Function
- Probably participates in a plant defense mechanism.
PTM
- This is a cyclic peptide which contains three disulfide bonds 4-20; 8-22; 13-27.
Literature Information
- ·Literature 1
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Title
- A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability..
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Pubmed ID
- 16872274
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Reference
- Biochem J. 2006 Nov 15;400(1):1-12.
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Author
- Ireland DC, Colgrave ML, Craik DJ.
- ·Literature 2
-
Title
- Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif.
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Pubmed ID
- 10600388
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Reference
-
Author
- Craik DJ, Daly NL, Bond T, Waine C.