General Information
-
DRAMP ID
- DRAMP00823
-
Peptide Name
- Cycloviolacin-O20 (Plant defensin)
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Source
- Viola odorata (Sweet violet)
-
Family
- Belongs to the cyclotide family
-
Gene
- Not found
-
Sequence
- GIPCGESCVWIPCLTSAIGCSCKSKVCYKD
-
Sequence Length
- 30
-
UniProt Entry
- P85183
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Insecticidal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- No specific N-terminal
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C-terminal Modification
- No specific C-terminal
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27.
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Stereochemistry
- L
-
Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00823.
Physicochemical Information
-
Formula
- C134H216N34O41S6
Absent Amino Acids
- FHMNQR
Common Amino Acids
- C
Mass
- 3151.75
PI
- 7.76
Basic Residues
- 3
Acidic Residues
- 2
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- -6.09
Hydrophobicity
- 0.443
Aliphatic Index
- 74.67
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7365
Absorbance 280nm
- 253.97
Polar Residues
- 15
DRAMP00823
Comments Information
Function
- Probably participates in a plant defense mechanism.
PTM
- This is a cyclic peptide which may contain three disulfide bonds 4-20; 8-22; 13-27.
Literature Information
- ·Literature 1
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Title
- A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.
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Pubmed ID
- 16872274
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Reference
- Biochem J. 2006 Nov 15;400(1):1-12.
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Author
- Ireland DC, Colgrave ML, Craik DJ.