• DRAMP ID

    • DRAMP00833
    • Peptide Name

    • Cycloviolacin-Y1 (Plants)
    • Source

    • Viola yedoensis (Chinese herb)
    • Family

    • Belongs to the cyclotide family
    • Gene

    • Not found
    • Sequence

    • GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN
    • Sequence Length

    • 33
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antiviral
    • Target Organism

      • [Ref.18081258] Anti-HIV activity:EC50=1.2μM, IC50>4.5μM.
      • NOTE:EC50 refers to the values for HIV-infected cell cultures, IC50 refers to the values for uninfected cell cultures.
      • [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=1210 nM).
    • Hemolytic Activity

      • [Ref.18081258] It has hemolytic activity.
    • Cytotoxicity

      • [Ref.18008336]CEM-SS cells:IC50>4470 nM.
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Cyclization (N termini to C termini)
    • C-terminal Modification

    • Cyclization (N termini to C termini)
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29.
    • Stereochemistry

    • L
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00833 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00833.
    • Formula

    • C145H203N35O49S6
    • Absent Amino Acids

    • AHKMQRVW
    • Common Amino Acids

    • G
    • Mass

    • 3412.77
    • PI

    • 3.67
    • Basic Residues

    • 0
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 5
    • Net Charge

    • -2
    • Boman Index

    • -11.5
    • Hydrophobicity

    • 0.142
    • Aliphatic Index

    • 23.64
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 4845
    • Absorbance 280nm

    • 151.41
    • Polar Residues

    • 25

DRAMP00833

DRAMP00833 chydropathy plot
    • Function

    • Has anti-HIV activity. PTM
  • ·Literature 1
    • Title

    • Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.
    • Reference

    • J Nat Prod. 2008 Jan;71(1):47-52.
    • Author

    • Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.
  • ·Literature 2
    • Title

    • Cyclotides as natural anti-HIV agents
    • Reference

    • Biopolymers. 2008;90(1):51-60.
    • Author

    • David C Ireland, Conan K L Wang, Jennifer A Wilson, Kirk R Gustafson, David J Craik