General Information

    • DRAMP ID

    • DRAMP00833

    • Peptide Name

    • Cycloviolacin-Y1 (Plants)

    • Source

    • Viola yedoensis (Chinese herb)

    • Family

    • Belongs to the cyclotide family

    • Gene

    • Not found

    • Sequence

    • GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN

    • Sequence Length

    • 33

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.18081258] Anti-HIV activity:EC50=1.2μM, IC50>4.5μM.
      • NOTE:EC50 refers to the values for HIV-infected cell cultures, IC50 refers to the values for uninfected cell cultures.
      • [Ref.18008336]Virus:HIV:inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells(EC50=1210 nM).

    • Hemolytic Activity

      • [Ref.18081258] It has hemolytic activity.

    • Cytotoxicity

      • [Ref.18008336]CEM-SS cells:IC50>4470 nM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Cyclization (N termini to C termini)

    • C-terminal Modification

    • Cyclization (N termini to C termini)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00833 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00833.

Physicochemical Information

    • Formula

    • C145H203N35O49S6

    • Absent Amino Acids

    • AHKMQRVW

    • Common Amino Acids

    • G

    • Mass

    • 3412.77

    • PI

    • 3.67

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -2

    • Boman Index

    • -11.5

    • Hydrophobicity

    • 0.142

    • Aliphatic Index

    • 23.64

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 4845

    • Absorbance 280nm

    • 151.41

    • Polar Residues

    • 25

DRAMP00833

DRAMP00833 chydropathy plot

Comments Information

    • Function

    • Has anti-HIV activity. PTM

Literature Information

  • ·Literature 1

    • Title

    • Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

    • Reference

    • J Nat Prod. 2008 Jan;71(1):47-52.

    • Author

    • Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.
  • ·Literature 2

    • Title

    • Cyclotides as natural anti-HIV agents

    • Reference

    • Biopolymers. 2008;90(1):51-60.

    • Author

    • David C Ireland, Conan K L Wang, Jennifer A Wilson, Kirk R Gustafson, David J Craik