General Information
-
DRAMP ID
- DRAMP00834
-
Peptide Name
- Cycloviolacin-Y2 (Plants)
-
Source
- Viola yedoensis (Chinese herb)
-
Family
- Belongs to the cyclotide family
-
Gene
- Not found
-
Sequence
- GGTIFDCGESCFLGTCYTAGCSCGNWGLCYGTN
-
Sequence Length
- 33
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- No specific N-terminal
-
C-terminal Modification
- No specific C-terminal
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys7 and Cys21; Cys11 and Cys23; Cys16 and Cys29.
-
Stereochemistry
- L
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00834.
Physicochemical Information
-
Formula
- C141H202N36O48S6
Absent Amino Acids
- HKMPQRV
Common Amino Acids
- G
Mass
- 3361.73
PI
- 3.67
Basic Residues
- 0
Acidic Residues
- 2
Hydrophobic Residues
- 7
Net Charge
- -2
-
Boman Index
- -6.11
Hydrophobicity
- 0.285
Aliphatic Index
- 38.48
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8855
Absorbance 280nm
- 276.72
Polar Residues
- 24
DRAMP00834
Comments Information
Function
- Has anti-HIV activity. PTM
Literature Information
- ·Literature 1
-
Title
- Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.
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Pubmed ID
- 18081258
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Reference
- J Nat Prod. 2008 Jan;71(1):47-52.
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Author
- Wang CK, Colgrave ML, Gustafson KR, Ireland DC, Goransson U, Craik DJ.