General Information

    • DRAMP ID

    • DRAMP00858

    • Peptide Name

    • Kalata-B3 (Plant defensin)

    • Source

    • Oldenlandia affinis

    • Family

    • Belongs to the cyclotide family

    • Gene

    • OAK2

    • Sequence

    • GLPTCGETCFGGTCNTPGCTCDPWPICTRD

    • Sequence Length

    • 30

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Insecticidal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref:11535828] It has hemolytic activity

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • No specific N-terminal

    • C-terminal Modification

    • No specific C-terminal

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys27.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00858 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00858.

Physicochemical Information

    • Formula

    • C127H193N35O44S6

    • Absent Amino Acids

    • AHKMQSVY

    • Common Amino Acids

    • CT

    • Mass

    • 3106.5

    • PI

    • 4.03

    • Basic Residues

    • 1

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 4

    • Net Charge

    • -2

    • Boman Index

    • -33.7

    • Hydrophobicity

    • -0.197

    • Aliphatic Index

    • 26

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5875

    • Absorbance 280nm

    • 202.59

    • Polar Residues

    • 18

DRAMP00858

DRAMP00858 chydropathy plot

Comments Information

    • Function

    • Probably participates in a plant defense mechanism. Has hemolytic activity.

    • PTM

    • Kalata-B3 are cyclic peptides which may contain three disulfide bonds 5-19; 9-21; 14-27.

Literature Information

  • ·Literature 1

    • Title

    • Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis.

    • Reference

    • Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10614-9.

    • Author

    • Jennings C, West J, Waine C, Craik D, Anderson M.