• DRAMP ID

    • DRAMP00861
    • Peptide Name

    • Kalata-B6 (Plant defensin)
    • Source

    • Oldenlandia affinis
    • Family

    • Belongs to the cyclotide family
    • Gene

    • OAK2
    • Sequence

    • GLPVCGETCFGGTCNTPGCSCSSWPICTRN
    • Sequence Length

    • 30
    • Protein Existence

    • Protein level
    • Biological Activity

    • Insecticidal
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • [Ref.20564013] HD50=7.7±1.3 μM against Human red blood cells.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • cell membrabce
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • No specific N-terminal
    • C-terminal Modification

    • No specific C-terminal
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys5 and Cys19,Cys9 and Cys21,Cys14 and Cys27.
    • Stereochemistry

    • L
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00861 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00861.
    • Formula

    • C124H192N36O42S6
    • Absent Amino Acids

    • ADHKMQY
    • Common Amino Acids

    • C
    • Mass

    • 3051.46
    • PI

    • 5.96
    • Basic Residues

    • 1
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 5
    • Net Charge

    • 0
    • Boman Index

    • -23.92
    • Hydrophobicity

    • 0.08
    • Aliphatic Index

    • 35.67
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5875
    • Absorbance 280nm

    • 202.59
    • Polar Residues

    • 20

DRAMP00861

DRAMP00861 chydropathy plot
    • Function

    • Probably participates in a plant defense mechanism. Has hemolytic activity.
    • PTM

    • Kalata-B6 are cyclic peptides which may contain three disulfide bonds 5-19; 9-21; 14-27.
  • ·Literature 1
    • Title

    • The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.
    • Reference

    • Chembiochem. 2007 Jun 18;8(9):1001-1011.
    • Author

    • Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.