General Information
-
DRAMP ID
- DRAMP00862
-
Peptide Name
- Kalata-B7 (Plant defensin)
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Source
- Oldenlandia affinis
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Family
- Belongs to the cyclotide family
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Gene
- OAK3
-
Sequence
- GLPVCGETCTLGTCYTQGCTCSWPICKRN
-
Sequence Length
- 29
-
UniProt Entry
- P58457
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Not found
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- [Ref.20564013] HD50=55.2±1.3 μM against Human red blood cells .
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- cell membrabce
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- No specific N-terminal
-
C-terminal Modification
- No specific C-terminal
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys5 and Cys19,Cys9 and Cys21,Cys14 and Cys27.
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Stereochemistry
- L
-
Structure
- Bridge
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Structure Description
- Not found
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Helical Wheel Diagram
-
Predicted Structure
- There is no predicted structure for DRAMP00862.
Physicochemical Information
-
Formula
- C128H204N36O41S6
Absent Amino Acids
- ADFHM
Common Amino Acids
- C
Mass
- 3095.6
PI
- 7.77
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 5
Net Charge
- +1
-
Boman Index
- -23.28
Hydrophobicity
- 0.038
Aliphatic Index
- 50.34
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7365
Absorbance 280nm
- 263.04
Polar Residues
- 18
DRAMP00862
Comments Information
Function
- Probably participates in a plant defense mechanism. Has hemolytic activity.
PTM
- Kalata-B7 are cyclic peptides which may contain three disulfide bonds 5-19; 9-21; 14-27.
Literature Information
- ·Literature 1
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Title
- The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.
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Pubmed ID
- 17534989
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Reference
- Chembiochem. 2007 Jun 18;8(9):1001-1011.
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Author
- Plan MR, Göransson U, Clark RJ, Daly NL, Colgrave ML, Craik DJ.