General Information
-
DRAMP ID
- DRAMP00883
-
Peptide Name
- Cyclotide hypa-A (hypa-A; Plant defensin)
-
Source
- Hybanthus parviflorus (Violetilla) (Viola parvifloria)
-
Family
- Belongs to the cyclotide family
-
Gene
- Not found
-
Sequence
- SCVYIPCTITALLGCSCKNKVCYNGIPCAE
-
Sequence Length
- 30
-
UniProt Entry
- P58445
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Not found
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Bridge
-
Structure Description
- Cyclotides are plant-derived miniproteins that have the unusual features of a head-to-tail cyclized peptide backbone and a knotted arrangement of disulfide bonds.
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00883.
Physicochemical Information
-
Formula
- C135H220N34O41S6
Absent Amino Acids
- DFHMQRW
Common Amino Acids
- C
Mass
- 3167.79
PI
- 7.52
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- +1
-
Boman Index
- 2.45
Hydrophobicity
- 0.673
Aliphatic Index
- 91
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 115.69
Polar Residues
- 16
DRAMP00883
Comments Information
Function
- Probably participates in a plant defense mechanism.
Domain
- The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
PTM
- This is a cyclic peptide which contains three disulfide bonds 4-21; 8-23; 13-28.
Literature Information
- ·Literature 1
-
Title
- First cyclotide from Hybanthus (Violaceae).
-
Pubmed ID
- 11524112
-
Reference
- Phytochemistry. 2001 Sep;58(1):47-51.
-
Author
- Broussalis AM, Göransson U, Coussio JD, Ferraro G, Martino V, Claeson P.